Nothing always works. But calling aggressive and having a run stuffed by a blitz is reality. When gaining 2 yards is comparable to a fight to the death without aggressive slide protection, I'll stick to calling aggressive more times than not.
I want to run the football. If that means calling aggressive slide protection, so be it. Sometimes I'll get burned, sometimes I'll gain good yardage, and once in a while I will rip off a long run.