[Bellsprout]

I used to notice this when I had the 360 version. Players would disappear after being fatigued a certain amount and there was no way to get them back. I remember games where i'd be down to running backs at WR because all my WR's had been subbed out. And others where i'd have fullbacks at TE for the same reason. Annoyed the heck out of me. The only time I noticed it happening though is if I abused the "Restart Game" option. I don't know if that's what you've been doing, but that could be it.

I think that "Restart Game" thing is broken. It allows injured players to play, and it screws with fatigue on occasion.

And no, I haven't noticed the problem since switching to PS3, but that might have something to do with Patch 1.