I have both pitcher stamina sliders at 10 and most pitchers still get gassed too quickly
Alot of relievers are gassed as soon as they enter the game. Even with the stamina slider at 10. The V3 rosters screwed up pitching in the game.
I would say that, due to the pitching stamina edits in v3, v2.1 would be the best to start a franchise with.