By CPU cheating, do you mean something like their DB's are basically running your route before your WR's do? Or weird random penalties again and again? Or turnover after turnover if you are ahead? Or getting all onsides kicks? Stuff like that?
It hasn't happened to me like that yet, but what has happened twice is the game has frozen late in the 4th while I was winning. I don't think that's indicitive of settings though.