[Watson]

It makes running a straight up read-option much easier. Also, if the defense starts keying on what side you're running to and is in man coverage, just flip it and read the SS for an easy TD.

I don't like the rest of it because at some point you're going to hit a wall and most Pistol playbooks lack big plays, especially passes. If you want a effective pass play, it's either a PA Rollout or curls/flats (which you can only run so many times a game before routes start getting jumped)

edit: Jeremy has a good point with the TE/WR-LB mismatch thing, but there's still little "big play" potential