Yes you can.. 3-4 pinch brings great pressure when the CPU is in 1 or 2WR sets.. 2-4-5 over storm brave or MLB blitz brings great pressure too when the CPU is in 3WR sets. All my friends play 3-4 Defenses and those ae the sets they bring pressure from and they get a good amount of sacks per game with those. You just take the chance of getting burned though. They also drop there OLBs down at the end position in dime, dollar, or quarter defenses.