Fingers are crossed this year for Franchise Mode!
I do have two main concerns this year (and I think I'm in the minority):
Here's hoping the developer-created rookies' potentials (or names) are somewhat randomized this year. I hate knowing who the good players are before I even scout them! Make me invest precious scouting points (or whatever they refer to it as) to find the gems in the draft. Also, randomizing potentials will keep both online and offline franchise modes from becoming stale.
Also, I hope they make drafting great players much more challenging this year. There were way too many A-potential players in Madden 11 (seemed even easier than '10 to draft A's in every round).