This I guess is partly what makes it difficult to tune analog for everyone...
Personally I don't have much trouble inside (R vs R, from behind the pitcher), since my natural thumb movement is from 8 to 2 o'clock. But if I need to go outside, I just cannot move my thumb reliably from 4 to 10 o'clock.
I think there's some user skill factor in pitching to inside/outside wide off the strike zone, I believe you almost have to go more than 45 degree angle off the center axis to do this, and that can be difficult (for me at least). Narrowing the strike zone to analog mapping was an idea discussed earlier... I also hope there was something done on the issue, but some people don't appear to have problem (like nem), so who knows... it might be our thumbs who need some practice and exercise....