Are you going into the Defensive Settings and setting up how you want each player covered? I go through and set that up every game and it helps, especially on how you want your defenders to defend against screens and pick and rolls. That will keep your players on their man, at least on the ones who are dangerous outside shooters who shouldn't be left alone on the perimeter. I am going to make some slider adjustments after this weekend as I'll be out of town till Monday.