Personally, I would stick to a tweaked version of default AA.
I'm getting closer using that. I raised the CPU QBA to 100, increased the CPU RB slider to 75, and lowered interceptions for both teams to 30.
I am in a dynasty right now, and playing as Syracuse vs USC, and I can't quite get Barkley right. Getting closer though. Last game he was 26/44 for 263 4 TD's and 3 INT. He's making about 5-7 bad decisions, which tells me to increase the slider up some. Ideally I want it at 2-3 poor decisions.
Sorry to get off topic, and rant...with Oregon, you can't really play with sliders slanted to dumb down the offense and boost the CPU defense. Not only will your lineman not do things right, the CPU will not get fooled on much of anything you do offensively.
Which is why I suggest sticking to sets that are close to default.