I would give it a yes and a no answer. First, we all know that line play needs work, so there it may not matter as much as it does for say the defensive backs.
Another thing is, play calling. If you prefer man to man corners, you better call more man defense to take advantage of your corners, otherwise they will get shredded in the zone.
So, I would say it works for some positions, and it doesn't work that well for others.