Hey Charter make sure you put your Offensive pass defense sliders ( Reaction time, Int, Pass Rush) below 75 combined to get all Madden locked in. I had mine at 93 and the CPU played very lethargic but once i put each section below 75 the CPU played enormously better.
I thought it was under 300 but i have found the CPU is very challenging with each section at 75 or lower.
Of course dont take my word for it try it out.