Those some of those sliders look like my older settings. I had to change some of those up. They look tough though.. I'm suprised the CPU isn't running crazy on y'all with those settings. When I had it like that the CPU was breaking way too many tackles so I decided to lower there breaktackles and raise there runblocking. Too many big plays were being giving up with there tackling too high.. You have the USER tackling low too so I know it has to be crazy.. I also see you have the USER catching on 45. That's probably why your friend are struggling on offense.. There's was just a few too many drops with the catching on 45. 50 really is the perfect spot.
Edit- I see you have the threshold at 100 so I guess that's why you had to change up some things..