Why do you wanna turn the USER INTs up that high? You'll be killing the CPU if you turned the USER INTs up that high. You have to lower the USER pass reaction to 25 to keep that total category at 75 which would just make it brutal for the CPU to pass the ball. You can lower the USER pass reaction to 55 and raise the USER INTs to 20 or lower the USER pass reaction to 50 and raise the USER INTs to 25. That's the lowest and the highest you should go with the USER pass reaction and USER INTs and keep the CPU somewhat competitive with there passing.
The autosubs is broken man. You'll habe too many other positions subbing out that shouldn't be if you mess around with the fatigue and stuff so I just leave it how it is on the front page. I always manually sub my RBs into certain packages every game anyway so they can get there carries. I've always done it myself anyway because I like setting up my own packages for the RBs.