I just played a game with these settings and it's hard to getting any better. I used the default CFM rosters that aren't updated to be as the teams are now. I used the Cowboys and beat the Chiefs 24-20. It took an almost perfect game to pull it off. I had no TO's and they had 3 and I still barely won.
The thing is I didn't feel cheated or that the CPU cheated or anything. I might had too many holding penalties but, I had a back up LT I because of an injury and most were on him. It seemed his lack of skill and Hali caused him to hold more.
Alex Smith had 63% completion and 7.9 average per attempt.
I had 76% with Romo but , it was a lot of short passes. 7.7 YPA.
Even the stats aren't too bad. I'm just tired of worry about it. I think I'm good to go!