Your saying your throwing picks every game? How many? The sliders & penalties interact with one another, it can be complicated, and it isn't straight forward, as we would think it would be.
What I would do to is this for starters:
CPU Pass Defense Sliders:
PRT: 30
INT: 0
PC 52
Penalties Settings
DPI 30-40
OPI 74-86
Let me know if this helps you?
For instance, in offline CCM if your fumbles slider is between 44 to 50 CPU run game isn't very effective, once you start to lower your slider for fumbles the cpu starts to run better. But, of course other CPU slider & penalty settings affect this as well.