I can tell ya that using the the RS to lead pass or throw a low trajectory pass on a curl route while dropping back will result in inaccurate passes on M25. I feel you have to get your feet set with if your going to use pass trajectories and throw certain passes. Now Elite QB's may get away with it but average joes were not in my experience with custom sliders to boot.
Again I think once we get sliders going this game has a high ceiling to play really freaking crazy good.