In the past (and with NCAA) my experience has been that higher IG settings have lead to better decision making by the QB...
Lower makes them "stick with the play" often to their overall detrimient...
80 has been the "sweet spot" for that (for me) for a while now...
RTP does influence the "abandon" that the DL takes en route to the QB, so lowering below default may slow the rush / lower sacks...
Interesting thought...
Maybe start with 40 there?