Nice post, OP!
I esp. concur with your take on IG and RTP, which IF they were as responsive as they had been in past iterations, could be used to take on the sack issue...
I'd also suggest raising False Start and Holding, while lowering Offsides should give the OL a chance against the rush...
I've been advocating something like:
Offsides 40 (less jump for DL)
False Start 60 (more jump for OL)
Holding 60 (longer duration of block)
Mask 55 (actually gets called around this number)
DPI 100 (knocks receivers off their route in press coverage, like real life)
OPI 100 (keeps up with the aggressiveness of DPI)
KR /
PR 50 (too hard to quantify, so default)
Clip 55 (actually gets called)
IG 80 (tested extensively with past iterations and NCAA...best overall pocket presence, IMO)
RTP 5 (slow the bull rush)
RTK 50 (too hard to quantify, default)