Hey Gutter, I tried the tweaks out last night (I played the Colts vs Broncos game over and over and over) and there was a degree of improvement though I will still slightly struggling to get pressure which I could be the matchup I suppose. I did mess around tried dropping the CPU pass blocking mark to 98 which did lead to more pressure on Manning's throws to the point I was seeing bad throws.
I struggle to run at the best of times (I need to break a bad habit of panic hitting acceleration burst straight off), so I put my RB at 53 which seemed to give a fair balance for me. I should factor in too that I'm using the actual Colts O line who have shocking AWR on the interior.
I think my stick skills aren't quite up to scratch so a slightly easier version of these sliders is working well for me, good work my man!