If only it were that easy. OPI/DPI are the only sliders that seem to
strictly affect WRs/DBs.
PCV will affect both the run and pass games. PCV at low settings helps DBs stick to receivers running their routes; but if you keep it too low, and it will open up the run game too much (WRs sticking to coverage instead of covering the run). Too high and they just run around and try to bat down passes without actually covering their receivers.
Pass reaction is more of a defensive run/pass ratio. Above 50 and they play the pass more. Lower than 50 and they play the run more.