I started noticing my #1 and #2 WR's not being in the game late when I needed them.
Auto subs are not working great.
Using 15 minute quarters guys are gassed by the 4th quarter on defense.
53 has felt much better and making package subs helps keep your line fresh on the DL. RB's will still be subbed out and you should also use formation subs in game to get your RB rotation set.