If you'd like to open up the CPU run game and see less tackles by your SS, lower HUM INT to 35 or 40...
In addition to "pick versus drop" and coverage, that slider has a "universal ball awareness" aspect to it that sees players flow to the ball faster and more effectively at default and higher...
You'll also see more passes defended because they tend to swat more and go for the pick less...
There's a whole lot of "goodness" unlocked by simply lowering that one HUM INT slider...