I could understand this working b/c fatigue is progressive, meaning if the longer the time span in between plays, the more recovery time the player's have, which would in turn keep them from subbing as often.
KBlover mentioned this year's ago but never really tried turning acc. Clock off, to my knowledge.
Im going to test 50 Fatigue w/ No acc clock and 9min qtrs to test it out tonight. Default autosubs for now, just testing to see how they fatigue and sub.