You will be fine. The sliders are very manageable in that regard. You will see more picks though that is for sure. I think the sliders in place make it so if you make a mistake you will pay for it in the passing game. But bumping up CPU pass block will surely make it very hard to get sacks.
These may also be too easy for you. Do you user catch? Do you play true no switch defense on the defensive cam?
Remember I do these things and it is a vastly different game with those house rules. I developed these sliders with that exact playing style. I can't attest to switching on defense, user catching and playing defense in default camera mode.