With the progression system being heavily weighted on stats, a big injury to a QB can derail a franchise, added to this the a lot of superstar QBs come in each draft then I reload if a major injury happens too often whilst simming a week. I don't want to get to year 3+ in my CFM and have few recognisable names as the draft players take over.
There are lots of injuries I will keep as it tells a story, big name player goes down, back-up makes the probowl etc. I like to see that on other teams.
As for the CPU logic during the draft and free agency, it can be awful... so reloading at the beginning of free agency or the start of the draft and rerunning it so the CPU signs different players is okay... otherwise I'd have to go into certain teams and control coaches which takes a lot longer. CPU will draft 4-3 players in the 3-4, 1st round QBs despite having spent a 1st round the previous year etc