I've actually bumped it back up to 50 in the latest ver that we'll be rolling with when the file starts. I think it is fine for in-game. It feels a high for simmed games, lots of injuries if you have to sim.
I'm expecting INTs to start high as guys adjust to the game and learn to check down more. And yeah, I also don't think All Pro vs All Madden is drastically different when it comes to User v User games. I feel like running is tougher on AM and QBs are less accurate, and that's the main thing.
I'm actually still worried that offenses will be too powerful at 60 SPD and that I'll have to keep bumping that up to keep deep bombs in check. But I'll wait to see if that happens before acting.