Even experienced players can have problems with Domination each year. I've played way too much 2K15 and 2K16 and I think I lost to the Jazz twice before I beat them. Though, when I did, I beat them quite easily, 60-48. And with a pretty modest lineup. And, frankly, I didn't even play well:
http://2kmtcentral.com/17/lineups/46...nation-vs-jazz
For Domination, difficulty level is not high and, except for the All-Star teams, the competition is not very good. So it's really about execution, gameplay skill, and discipline.
My SF's were Brandon Ingram and Evan Turner, both of whom being merely adequate defenders, at best.
Rudy Gay is not much of a defender, himself, only about on par with these two Silvers. But MKG is a legit on-ball stopper.
I think the issue is that Hayward isn't hard to contain, when it comes to on-ball 1-on-1 defense. He's not fast, he's definitely not explosive, doesn't really have handles, and doesn't have very good ability to finish driving dunks and layups if contested. MKG can easily shut him down in that scenario.
The issue you had, and which I often have, is the CPU running plays with off-ball screens that leave wing shooters WIDE open. And unless the defender has elite Def IQ, he is going to get caught up in off-ball screens. Even if he is elite.
What you can try to do is to increase pressure on Hayward with Deny Off-Ball defense. But the defender can still get stifled by screens. So what you really need to do is to watch the court and pay attention to Hayward's teammates as they make moves to lay down screens for him. As you see a guy going over to Hayward, off-ball, be prepared to switch to Hayward's defender to get around the screen and be in position to contest a shot if Hayward receives a pass. Or deny the pass altogether.
These catch-and-shoot sort of guys can be easily contained if you pay attention like this. It's the really explosive guys with crazy handles, like D-Rose with the Knicks, who can't really be contained one-on-one.