I've been using a similar set blend of front page and the 40 parity set.
I use slow speed, 100 parity, 15min/15clock. Catch at 45/45 to keep both completion %s down. Fumbles at 60/60 because I see plenty. Front page special teams. Then I left user pass block at 5, run block 44, reaction 5, coverage 90.
So basically the user settings are front page and the cpu settings are this set just for a little challenge. I went 5-2 with good results, minus robo qbs putting me at 21st in pass yards against and I was leading in pass yards with geno smith.
Now I think I'm going to keep the veterans on defense on my team instead of trading them for draft picks. Then go back to pass block at 5/5 or 5/6 because I think you're going to need it at slow speed and higher parity. Then maybe bump run blocking for cpu from 70 to 72/73? 75 is bad, but at 70 I still lead the league in rush against even after facing Jamal Charles who I hate playing against. Then I'll have everything just about perfect for me