Still waiting on response from dev team if Pass Rush Slider was completely removed and if so, what replaced it.
Some believe the Pass Reaction Slider is just renamed.
The ZCV rating dictates individual player reaction to ball release from QB's hand.
The issue I've found are a that rosters/draft classes have most DB's already 80+, so when increasing the Pass Reaction Slider, the few Def players under 80 are given an increase which then makes every player break before the ball leaves the QB's hand (i.e. Psych Defense on pass plays).
QB THP also has a huge affect on player reaction also.
90+ is a killer dealing with this issue, as there's nothing you can do to slow the ball speed down in relation to Def player reacting.
What exactly (i.e. positions etc..) are you trying to accomplish?