About 5 to 10 times a game I have to go in and choose a specific running play because they are never listed. This helps me mix it up.
EDIT: On a side note calling different plays each time will also confuse the defense. Im not sure if this part of the AI or not, but it seems to me that calling the same play more then 2 or 3 times and the defense starts shutting it down. Maybe its just.