I toyed with a couple of other things last night to see if we could slightly boost the offense. Either they didn't do it or they did it WAY too well.
I'm pretty much now sold on setting the 0 MM fatigue for my personal use. This approach has done well for me on NCAA 14 and now on Madden. I'm going to leave the 50 MM fatigue as an option as it DOES work fine....my suspicion is that most people will gravitate towards the 0 fatigue setting.
To your concerns....penalties are fine from what I have seen (i.e. not much difference between the 50 and 0 settings). Injuries....well they are what they are....but funny thing is, I think the 0 MM fatigue will actually improve them long-term.