MAY is the operative word...which even in my thread is the reason why I include it as a recommendation...if I am wrong, that is fine because it also removes any potential boost like you seemingly get for some of the scheme settings.
In theory, if we assume that they do indeed impact the play on the field, then setting the DEs to 'Speed Rusher' would be the most logical setting for you to try out.
But like with all settings in Madden. it's very much relative to all of your other settings. Some slider settings could 'drown out' those types of impacts, if they are there.