I have messed with this a bit today. I went as high as 57 offsides, 55 fs, 57 holding and putting all lineman on undisciplined penalty trait. The result was no effect. If there is any effect there has to be a wider gap but haven't tested that yet. Honestly it looks like its not worth it. However I discovered if you want to open up the run game without messing with run block just tweak the penalty sliders.
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