Only if I call the plays, because human is obviously smarter than Madden CPU in playcalling.
If I pick just the first suggested play in the 'Strategy' suggestions the results are pretty close if you play on defense or TE/WR; if you play QB in a passing team or HB in a ground£ one it depends on your stick skills and play vision ability.
These sliders anyway are designed for a CPUvCPU style since it's pretty impossible to set sliders in a scientific way if a user actually plays the game...