As I said previously, I prefer running with the 75 man roster. I have used EA preseason and week 1 rosters and they seem OK.
This is so daggone true, moreso than last year (and I thought it was great then). I look for very specific skill sets for a number of positions and roles to fit what I am trying to do and many times, that player is not the guy with the highest overall. With the NFL being so specialized, this is really true-to-form.
I'll need to check out the 0/50 injury setup with this patch....
But yeah, 1 click (especially in a default environment) can indeed have a pretty dramatic impact on how things play out. I think you could put together a meaningfully different experience just by tweaking sliders between 49-51.