You can get open/lightly contested mid range shots/3s off pick and roll.
If you have some momentum going to the rim tilt the right stick into the defender to attempt to draw fouls.
Set plays can get you open 3s off down screens and plays with floppy action.
One on one can be tough but it's doable. If the cpu plays you tight sometimes it's better not to use turbo and drive with just the left stick.
TL;DR: It's possible, you just have to know all your options and take what the defense gives you.