This is what I have set in my NVidia CP and In game. Results may very based on your system horsepower.
Just for reference my system specs
My Settings
With this I have no issues with the game at all and no issues with graphics disappearing like kick meter or play art. If I had MSAA 2x or 4x turned on in game I would lose them. Again not saying my stuff is the best way, its just how I run the game and I think it looks very good with this setup.