No.
Isolation defense is a very small chunk of PG defense. It makes up less than 10% of all these player's possessions.
Rose is a bigger PG (logged more mins at SG than PG in 2019) so he should be a more effective in Isolation. His athleticism/length made up for his lack of IQ when younger with Chicago. Simply looking at one area does not define whether a player is a good defender or not.
Derrick Rose (2019)
ON-BALL DEF
34% PnR: 1.01 PPP (168 poss) - 14th percentile
7% Post-Up: 0.56 PPP (32 poss) - 94th percentile
5% Isolation: 0.53 PPP (26 poss) - 96th percentile
OFF-BALL DEF
32% Spot-Up: 1.02 PPP (157 poss) - 49th percentile
10% Off-Screen: 0.92 PPP (49 poss) - 52nd percentile
8% Hand-Off: 0.76 PPP (41 poss) - 77th percentile
We can very clearly see Rose (in 2019) was an effective defender 1v1 but got abused in PnR. Probably has the biggest split in the league between his Iso/Post and PnR defense.