Though I have given up on 20, I used to play this way a lot. The only sliders that need to be changed are the xp sliders. I usually leave auto sub at default as those are unnecessary to change in my opinion. The normal sliders are gameplay sliders and do not affect simulated games as in advancing to the next week.
I have in each of the last 3 maddens before 20 with different teams, simulated 25 seasons worth of games with sliders I have not changed from default and had positive results.