On All-Pro I do Human Accuracy 35, Human Catching 49 Human Run Block 25, AI Accuracy 49 AI Run Block 49 (I usually only play offense to stop human X-Factors from warping the game).
On All-Madden, I did Human Accuracy 90 with all other sliders at 50 (except AI Accuracy at 49 to stop robo-QB stats), and that seemed to work better. Still need to test it more.