Yes. in Main Menu set the CPU and Player game play sliders up then import them into franchise. On the Slider Sheet there are 6 Boxes that have both Play now and Franchise Penalty values in them. Whatever difficulty you are playing then in franchise change the penalty values to the values in one of the 6 boxes on my slider sheet.
I recommend setting my sliders up including the Injuries, Fatigue, Player Speed and penalty values up in the Main Menu then import them into franchise that way all you will have to do then is look at the difficulty that you are using in 1 of the 6 boxes on my slider sheet and change the penalty values that i listed for each difficulty.