We have a different experience. I run (Multiple offense) HB Direct from the Gun Trips HB Weak formation. The HB lines up on the left side of the QB and runs it up the middle. If this is the type of play he's facing, an OLB blitz is doing him a favor. Pinch the DL. (Left D Pad -> LS Down) or slant the DL to the middle as well as the LBs if needed. The game "cheats" this play (a gaping hole up the middle), which is why I have a house rule that I have to be cheated by the CPU before I can run this play. I have not defended this, but that is what I'd do. I will be interested to know what you find that works.
BTW: What defense do you run?