No, I can not, for the life of me, imagine playing this game with QB accuracy at 50. In SOS we have QB accuracy at 40 and we still have guys throwing perfect passes far too often. 2nd and 3rd string guys can come in and go off for 300 yards far too often.
I can't imagine playing the game with it over 40. It probably is more realistic at 35
I just finished a season with my QB, Brock Osweiler, at QB, winning MVP (4200 yards, 37 TDs, 14 INTs, 69 completion percentage, 11 yards per attempt). That is with accuracy at 40.