It's been years that i've been having a lot of different problems with the similar issues, i've had a numerous posts about how not online but offline game/gameplay is HIGHLY affected by your ISP connection to 2k servers which i've been suffering for years since the PS4 era has started that is since 2k has started to collect our in game data 24/7 so that every move every input everything you do in the game have been collected by the server so that if the connection is not a good between 2k servers and your ISP then you get different problems along the way which i believe this settings not being saved or having different problems related to settings or different issues FE i've had numerous problems in which the game i couldn't even move my joystick on the menus just stuck for a while and more. So that is probably right and correct that your connection 2k server affects you and your settings don't get applied on the 2k server cache, which technically ofcourse i don't know how and why.
I also have problems in MLO mode in which i simulate some games and they don't get simulated every once in a while as if the server doesn't accept eventhough i see in game it's started simulating yet no results been made so.
A lot of other issues i can name... I wish we would go back to PS3 era when 2k didn't bother getting your data 24/7.
EDIT: I may give you a fix for you to try on which is again very odd as the problem itself when you think about it. Change your settings and get to play now mode and let the game play on DEMO mode until the end of the demo game then have a look at it. Or the opposite open the game get to the DEMO mode wait until demo game is over and change your settings.
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