The most important thing to do is upgrade your best weapon's damage to the max... I suggest the plasma cutter. Baddies take more hits than usual in Impossible mode, so every node filled on your weapon helps a TON... In addition, pack only one or two weapons, so you can make space carrying ammo and health kits. Sell the ammo that you don't need.
If you encounter more than two baddies in one room, prioritize. I always stasis the one closest to me, then the ones further back. Aim low and take out the legs of the first stasis'ed guy to keep him immobile. If you're close enough to frozen enemies, go ahead and whack them with the melee to save ammo. If not, just get used to running backwards and repeating the freeze/kill process.
Just anticipate when the enemies will appear from your last run through and you should be okay.
Good luck.


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