One year my sister told me our dog ran away during the night right after I woke up, but I quickly realized she was joking especially since our dog (A Newfoundlan) was far to lazy to ever run away.
A few years later I emailed her and told her that her cat had run away in the subject line but inside it just said April Fools and Happy Birthday Vito (the cats name) as it was his birthday. Actually, the subject line wasn't entirely false as the cat kept running away from me when I was trying to take his picture.
My junior year in college one of my psychology professors was late getting to class and since the room was on the first floor, someone suggested that being as it was April Fools day we should all go outside so he walked into an empty room. Someone wrote a message of some sort on the board and we all went outside and someone watched in the window until he came into the classroom at which point we all went back in after a minute or so.

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