For me, I like to run set plays only off made baskets. I feel I have more time to think about what set I would like to run and select it quickly. Because the play calling in 2k10 can be slow depending on the play called and how your team is spaced on the floor, this helps me avoid playing late in the clock a lot; which was the case when I was running plays on almost every possession.
Off misses I like to obviously first look for an opportunity to score quickly in transition. If nothing is there and I have a big man trailing the play, I like to call for a quick pick for the ballhandler in hopes to break down the D before it gets completely set.
I also make sure to see if any mismatches were created in transition and look to exploit them, be it in the post or on the perimeter.
Lastly, if I'm forced to work in the half-court off a miss, I like to look for shooters coming off screens, run PnR's and PnP's, and look for my post players.
I know this is all basically Basketball 101 but just thought I'd share.

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