Yes,
I've never played on any speed but slow. Just a heads up if you gusy are wanting to open up the offense you can reduce threshold down about 5-10 and it'll seperate the speed guys a little more.
Or you can stay at 25 threshold and just boost up the RBA slider to 40. If your playing gun happy passing team and you need those 300-350 yard games just tweak the CPU's coverage a little
This level is very slider friendly and you don't have to be handcuffed to my exact settings.
Remember they are a base set just to get help get you guys in the right direction once you observe game play for a few games you'll know right away what sliders will best your team style or preference on the field.