I threw the game on HOF last night for some perspective and one thing that stood out compared to Pro is that the CPU defense is not aggressive at all. They'll pick off your poor passes and throw an easy-to-evade double team at your big men if they get rolling but by and large the game is a piece of cake offensively on Pro.
On HOF the CPU was denying my wing players some times, the PnR was much more difficult and I couldn't dunk on a everyone with Amare.